Create an Account Nfomedia Log in  Connect with Facebook
Home Blog

NRSC 2100 Blog

A GROUP WEBLOG FOR NRSC 2100 SUMMER NRSC 2100

« return

December 2, 2011

Alcoholism: Can it be Cured?


Alcoholism to this day is one of the most deadly and chronic diseases, that is interestingly controversial with regards to symptoms, treatment, diagnosis, and even heritability. How can a disease be so dangerous and historical and yet not even be remotely understood? As medicine, science, and technology move forward we are rapidly moving towards this inconceivable goal, but treatment is still only moderately successful along with progressive pharmacotherapies for all addictions.

A huge part of this lack of understanding of this disease is the fact that alcoholics are all different in a variety of ways; including their symptoms. There are numerous biological mechanisms as a result of alcohol addiction, all of them varying in their manners and withdraw. So recent studies show that these different mechanisms represent different stages of alcoholism, which could be relieved by different treatments. Regardless, these treatments have to block motivation to seek and consume alcohol.

Researchers have determined two categories: relief and reward drinkers. Reward drinkers drink to reward themselves the same way many drugs work, by activating brain reward pathways. Relief drinkers drink to relieve negative emotions, such as anxiety and feelings of withdrawal. Obviously these two varying types of alcoholics require different treatments.

It has also been discovered that alcoholism is marginally heritable. Genetic susceptibility is an alcoholic trait that can be passed down from generation to generation, however these varying types of alcoholism are largely based on environmental factors. These would include things such as how often the individual is exposed to stress or put in a circumstance of reward.

So now, is it possible to treat either one or both of these forms of alcoholism? Studies show that the reward system of alcoholism is mediated by a collaboration of endogenous opioids and dopamine release. Activation of dopamine in the mesolimbic pathway has been correlated to many other sorts of drug addictions. Dopamine is regulated in the corticomesolimbic system by a receptor known as MOR (mu-opioid receptor), which if blocked, prevents dopamine release caused by alcohol consumption. A drug known as naltrexone is an antagonist of opioid receptors, and is currently being researched as treatment for reward alcoholics.

Next is relief drinking. Relief drinkers drink to suppress stress, anxiety, discomfort, pain, and dysphoria. These alcoholics generally end up setting the stage for routine and frequent alcohol consumption to escape negative emotions. Recently, it has been discovered that release of CRF is central to this behavior. CRF (Corticotropin-releasing factor) is a peptide that is released into the anterior pituitary by alcohol consumption in relief drinkers, which in turn releases ACTH and stimulates cortisol release, reducing stress. CRF regulation and function is somewhat genetically determined, which makes a pharmacological cure more difficult and less likely to be successful. However, studies have shown that in individuals with naturally decent regulation of CRF could likely be treated for relief alcoholism; via CRF1 antagonism. Research is still ongoing as to whether this would be a sufficient method to treat alcoholics.

Alcoholism is a very complex disease, by which human understanding is challenged and pushed to therapeutic limits. This blog marks a tremendous step in the right direction towards understanding alcoholism and possibly curing the disease one day, but until that day comes there is plenty more to learn and to gain.

Heilig, Markus, David Goldman, Wade Berrettini, and Charles P. O'Brien. "Pharmacogenetic Approaches to the Treatment of Alcohol Addiction : Article : Nature Reviews Neuroscience." Nature Publishing Group : Science Journals, Jobs, and Information. 20 Oct. 2011. Web. 02 Dec. 2011. .

http://www.nature.com/nrn/journal/v12/n11/full/nrn3110.html
Posted by      Mark A. at 12:47 PM MST

Comments:

  Joshua s.  says:
We all interested in understanding the values of alcoholism at neuro science. Many informative updates it has listed to write my assignment for me and entries. So, I am glad to understand neuro science assignments in online classes.
Posted on Mon, 27 May 2019 11:08 AM MDT by Joshua s.
  Daniel S.  says:
computer forensics is the ark and science of locating digital evidence.
Posted on Tue, 26 Nov 2019 7:08 PM MST by Daniel S.
  milan j.  says:
Alcoholism is one of the deadly and chronic diseases Continue Reading nowadays. Here in this article, it share details regarding alcoholism and its consequences. I am looking for further updates over here. Hope that you will share it soon here.
Posted on Sat, 7 Dec 2019 10:47 AM MST by milan j.
  Shane F.  says:
Ok understood, but when you do tummy time activities 3 month old I have tried a lot of searches but none was found. Thanks.
Posted on Fri, 24 Jan 2020 6:30 AM MST by Shane F.
  jayaram b.  says:
Excellent Blog! I would like to thank for the efforts you have made in writing this post. I am hoping the same best work from you in the future as well.
I wanted to thank you for this websites! Thanks for sharing. Great websites!

Shareit
Shareit apk
Shareit pc
Shareit for Android
Shareit for Ios
Shareit latest version
Posted on Sun, 23 Feb 2020 6:43 AM MST by jayaram b.
  Ryan R.  says:
Alcoholism is always take a person to death,great article i was searching for this kind of article.
KedaIntelligent
Posted on Sun, 23 Feb 2020 11:05 PM MST by Ryan R.
  zeenabweb w.  says:
Great blog,alcoloholic persons must read this blog.
Sesame Seed Supplier
Posted on Sun, 23 Feb 2020 11:36 PM MST by zeenabweb w.
  jandercosmetics c.  says:
well written blog.
hydrosol manufacturer
Posted on Mon, 24 Feb 2020 2:46 AM MST by jandercosmetics c.
  cvindomas c.  says:
Posted on Mon, 24 Feb 2020 4:39 AM MST by cvindomas c.
  JFUTrading T.  says:
Posted on Wed, 4 Mar 2020 12:56 AM MST by JFUTrading T.
  Nathan J.  says:
Yes, it can. There have been multiple studies that revealed various therapies and cure for alcoholism. I mean, it poses a challenge but it's not impossible. Alcohol intake should be done moderately. Sydney criminal lawyers
Posted on Wed, 4 Mar 2020 10:08 PM MST by Nathan J.
  Emily N.  says:
With the right therapy and medication, YES. Thank you for sharing this amazing and relevant post. Nowadays, various organisations are working hand in hand to help people with alcoholism to recover. Tedx speaker Sydney
Posted on Thu, 5 Mar 2020 3:06 AM MST by Emily N.
  Charlie D.  says:
Love to read about that
fiberglass rod manufacturers
Posted on Mon, 16 Mar 2020 11:29 PM MDT by Charlie D.
  Sophia O.  says:
Amazing blog and shared in my contact list.
glass protective film supplier
Posted on Mon, 20 Apr 2020 10:59 AM MDT by Sophia O.
  zeenabweb w.  says:
Posted on Thu, 23 Apr 2020 8:46 AM MDT by zeenabweb w.
  Teligali C.  says:
thanks for the information https://independencedayoffers.co/
Posted on Fri, 7 Aug 2020 5:19 AM MDT by Teligali C.
  Hailu E.  says:
Leading Refrigeration Equipment Supplier. Shengzhou Hailu Refrigeration Equipment Co., Limited is located in Huangze Town, Changzhou City. Since its foundation in 1998, the company has made its name as a specialized Refrigeration equipment manufacturer in China. The company covers has become one of the dominant refrigeration equipment manufacturers producing the most complete product category and specifications in China.
Posted on Sun, 16 Aug 2020 11:22 PM MDT by Hailu E.
  Christian Mode W.  says:
Christian Mode Watches is one of the finest wrist watch manufacturers in Korea. We manufacture a good range of quality wrist watches. It provides the best stylish, and classic looking watches categorized in classic watches, wrist watches, analog watches having great quality with durability.
Posted on Mon, 17 Aug 2020 2:33 AM MDT by Christian Mode W.
  KA C.  says:
The Best DC Compressor Fridge Freezer Supplier in China
Shanghai KaCooler Auto Parts Co., Ltd. (KA Cooler) is a major international concern in the DC compressor fridge freezer sector. Cacular has a company policy on research and development regarding practical use, design, and performance of freezers.
Posted on Thu, 20 Aug 2020 11:17 PM MDT by KA C.
  NC A.  says:
High Quality Aluminum Profile Manufacturer
Being a leading aluminum profile supplier, we provide our customers with the best and durable quality products manufactured and supplied through a complicated process using the best quality materials that only we can provide without compromising on quality and quantity both.
Our company is well equipped and fully stocked with the finest quality modern machines that are updated according to the needs and requirements of the contemporary era making us one of the highest quality aluminum profile manufacturer in the market.
Posted on Wed, 26 Aug 2020 3:03 AM MDT by NC A.
  SZICG B.  says:
Shenzhen HURRAY WELL TECHNOLOGIES LIMITED, The Best private label skin care Manufacturers was established in 2004 „??We have branch in Shenzhen „??USA„??Hongkong, and has production base of research and development, The company has the international import and export rights and the United States invention patents, and access to national high-tech enterprises„?? We are the best private label skin care manufacturer company.
Posted on Wed, 26 Aug 2020 11:20 PM MDT by SZICG B.
  Longtai I.  says:
Best Automotive Motorcycle Parts Manufacturer in China
Ningbo Longtai Industry Co., Limited is a leading automotive motorcycle parts manufacturer in China. Ningbo Longtai now encompasses a 160,000 square foot impression. Begun as a high-quality parts business, Ningbo Longtai has formed into a multi-line motorcycle and ATV seller. Ningbo Longtai Industry Co., Ltd, which was established in 1998 and located in Yinzhou Zone, Ningbo, Zhejiang, China.
Posted on Thu, 27 Aug 2020 1:07 AM MDT by Longtai I.
  top s.  says:
Zonebao Molecular Sieve Co.,Ltd is a manufacuturer specilizes in molecular sieve serial products in Chin Our precept is using our sincerity and perspiration to win your trust and cooperation.top sieve
Posted on Wed, 7 Oct 2020 11:39 PM MDT by top s.

Want to post a comment? Please Log in or Create an Account.

 Copyright © 2007-2016 Don Cooper, Ph.D.. All rights reserved.